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. 2023 Jan 14;28(2):855. doi: 10.3390/molecules28020855

Table 6.

5-HT medicinal chemistry leads.

Molecule Name Primary Targets Secondary Targets References
124 3-Hydroxy agomelatine 5-HT2C [183]
125 8-OH-DPAT 5-HT1A [184,185]
126 7-Desmethyl-3-hydroxyagomelatine 5-HT2C Melatonin MT1, MT2 [186]
127 Agomelatine 5-HT Melatonin MT1, MT2 [187]
128 AR-A000002 5-HT1B [188]
129 AS19 5-HT7 [189,190]
130 Benzoctamine 5-HT [191]
131 PCPA methyl ester 5-HT [192]
132 U92016A 5-HT1A [193,194]