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LPS-induced TLR4 complex dimerization. (A) Schematic representation of LPS; (B) crystal structure of TLR4/MD-2/LPS complex, PDB code: 3FXI; (C) formation of a secondary dimerization interface between TLR4/MD-2/LPS and the second TLR4* complex; (D) positioning of E.coli lipid A in the binding pocket of MD-2 and lipid A participation in the dimerization process. Images were generated with PyMol.
