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The chemical structure of E. coli lipid A and the 3D-tertiary structure of MD-2-bound lipid A in relation to biological activity. (A) Chemical structure of E. coli lipid A; (B) tertiary structure of the diglucosamine backbone of TLR4 agonist lipid A variants bound to MD-2/TLR4 complex; (C) tertiary structure of the diglucosamine backbone of TLR4 antagonist lipid A variants bound to MD-2; crystal-structure-based design of synthetic TLR4 ligands.
