Table 2.
Summary of stimulus-responsive systems and methods to be able to respond to different stimulus.
| Stimulus-Responsive System | Methods | Functional Block | Reference |
|---|---|---|---|
| Ion-strength | Ca2+ can respond to free phosphate ions at the local bone defect | Ca–gellan gum (GG) hydrogel | [67] |
| pH | Acylhydrazone bond cross-linking and DA click covalent cross-linking | Bio-glass (BG) | [83] |
| Changes in osteoconductivity and osteoinductivity | Silica-based NPs | [84] | |
| Temperature | PEG-dithiothreitol (DTT) | [85] | |
| Pluronic F-127 (PEO®100PPO65PEO100) | [18] | ||
| Calcium lactate (CaL) | [86] | ||
| Light | UV-cleavable ester bond | Cholesterol-modified noncoding microRNA Chol-miR-26a | [87] |