Table 1.

miRNAs and associated targets/regulators involved in BCa recurrence.

miRNA	Target/Regulator	Function	Reference
MiR-22-3p	Not identified	Elevated miR-22-3p showed reduced recurrence-free survival (RFS).	[20]
MiR-34a	Not identified	Downregulation associated with recurrence and poorer prognosis [21]. Higher expression of miR-34a associated with lower likelihood of recurrence. MiR-34a upregulation showed less invasion and colony formation [22].	[21,22]
MiR-100	FGFR3	Reduced miR-100 associated with less recurrence. *	[23]
MiR-138	Cyclin D3	Downregulation of miR-138 linked to recurrence.	[23]
MiR-146a-5p	Two separate pathways involving YAP1 and COX2	Downregulation associated with recurrence. Subsequent regulation of ALDH1A1 and SOX2.	[24]
MiR-148a	Not identified	Downregulation of miR-148a in BC patients linked to recurrence and metastasis.	[25]
MiR-152	Not identified	Higher expression of miR-152 linked to lower RFS in NMIBC.	[26]
MiR-155	Not identified	MiR-155 upregulation associated with recurrence.	[27]
MiR-187-5p	Not identified	Oncogene, promotes proliferation and mobility while decreasing apoptosis.	[28]
MiR-200a family	Not identified	Reduced miR-200a-3p showed reduced RFS [20]. Lower expression of miR-200a in BCa, and downregulation linked to higher chance of recurrence [29].	[20,29]
MiR-210	Not identified	Higher expression of miR-210 found in patients with recurrence.	[30]
MiR-214	Not identified	Reduced miR-214 expression in BCa urines pre-op compared to post. Linked to RFS [31]. Mir-214 downregulation linked to recurrence [32].	[29,30,31,32]
MiR-221/222	Not identified	Downregulated in BCa, but miR-222 is upregulated in high grade/invasive BCas. MiR-222 upregulation (Ta/T1 cancers) linked to recurrence.	[33]
MiR-302b	EPS8 (potential)	Tumor suppressor, lessens proliferation, migration, and invasion. Promotes apoptosis.	[34]
Let-7f-5p	LIN28	Tumor suppressor, represses cell viability and migration.	[35]

* p value > 0.05.