Table 1.

Antifungal peptides with activity against A. fumigatus. The table presents the antifungal peptides of natural origin with their physicochemical parameters and minimum inhibitory concentration against A. fumigatus.

Author/Year	Name	Source	Length	Net Charge	Hydrophobic Residues	Boman Index	MIC
Mignone et al., 2022 [65]	Sin a 1	Seeds, white mustard, Brassica hirta	145	10	32%	2.09	63 µM
Seyedjavadi et al., 2019 [66]	M. chamomilla AMP 1	Matricaria chamomilla L.	23	3	47%	0.68	6.66 µM
Khani et al., 2019 [67]	Skh-AMP1	Leaves, Satureja khuzistanica	25	5	28%	3.19	20.7 µM
Xiaoxia et al., 2019 [68]	P. xylostella Moricin	Highly expressed in fat body and hemocyte, diamondback moth, Plutella xylostella	42	9	35%	1.67	8.9–23 µM
Park et al., 2016 [69]	Human alpha-synuclein	Brain, Homo sapiens	140	−9	35%	1.3	0.8–3.2 µM
Bellmonte et al., 2012 [70]	Hb 98–114	Tick midgut, Rhipicephalus (Boophilus) microplus	17	3	52%	−0.62	6.3 µM
Rodríguez et al., 2010 [71]	PgAFP	Penicillium chrysogenum RP42C; also found in Penicillium chrysogenum Q176	58	4	27%	2.63	0.12–1.0 µM
Gao et al., 2009 [72]	Meucin-18	Mesobuthus eupeus	18	2	55%	−0.66	1.9–8.3 µM
Simon et al., 2008 [73]	Human drosomycin-like defensin	Mainly expressed in skin (mRNA), Homo sapiens	43	5	25%	3.58	6.25 µM
Cabras et al., 2008 [74]	SP-B	Porcine salivary gland granules	21	1	9%	0.35	58.68 µM
Briolat et al., 2005 [75]	Catestatin	Skin, Homo sapiens	21	4	33%	1.98	80 µM
Briolat et al., 2005 [75]	Cateslytin	Chromaffin cells and in secretion medium, bovine	15	5	33%	4.3	10 µM
Landon et al., 2004 [76]	ARD1	Archaeoprepona demophoon	41	3	39%	1.6	ND
Kaiserer et al., 2003 [77]	Penicillium antifungal protein	Penicillium chrysogenum	55	5	25%	3.12	ND
Lauth et al., 2002 [78]	wb-Moronecidin	Skin/gill, Morone saxatilis	23	3	43%	0.38	50–100 µM
Silva et al., 2000 [79]	Gomesin	Hemocytes, Acanthoscurria gomesiana	18	6	33%	4.39	ND
Lugardon et al., 2000 [80]	Vasostatin-1	Bovine chromaffin granules, Bos taurus	76	−1	35%	2.03	1–10 µM
Gun et al., 1999 [81]	AnAFP	Aspergillus niger	58	5	28%	2.42	4–8 µM
Gallo et al., 1997 [82]	Mouse cathelin-related antimicrobial peptide	Adult testis, spleen, stomach, and intestine, mouse, Mus musculus	34	6	29%	1.74	100 µM
Lawyer et al., 1996 [83]	Tritrpticin	Synthetic fragment of porcine cathelicidin.	13	4	53%	2.9	ND
Ehret et al., 1996 [84]	Androctonin	Androctonus australis	25	8	28%	3.9	25–50 µM
Mor et al., 1994 [85]	Dermaseptin-B2	skin, giant leaf frog, Phyllomedusa bicolor, South America	33	4	54%	0.23	125 µg/mL
Mor et al., 1994 [85]	Dermaseptin-S2	Sauvage’s leaf frog, Phyllomedusa sauvagii, South America	34	3	52%	−0.14	20 µM
Mor et al., 1994 [86]	Dermaseptin-S3	Sauvage’s leaf frog, Phyllomedusa sauvagii, South America	30	6	53%	−0.25	10–20 µM
Mor et al., 1994 [86]	Dermaseptin-S4	Sauvage’s leaf frog, Phyllomedusa sauvagii, South America	28	4	71%	−0.91	20–30 µM
Mor et al., 1994 [87]	Skin peptide tyrosine-tyrosine	Skin, the South American arboreal frog Phyllomedusa bicolor	36	1	22%	2.69	100 µg/mL
Fehlbaum et al., 1994 [88]	Drosomycin	Fruitfly, Drosophila melanogaster	44	1	34%	2.56	6.25 µM
Bellamy et al., 1992 [89]	Lactoferricin B	Bos taurus	25	8	48%	2.75	ND
Mor et al., 1991 [90]	Dermaseptin-S1	Sauvage’s leaf frog, Phyllomedusa sauvagii, South America	34	3	50%	0.16	30 µM
Wnendt et al., 1990 [91]	Antifungal protein	Aspergillus giganteus	51	9	31%	2.1	1 µM
Miller et al., 1989 [92]	Secretory leukocyte protease inhibitor	Tears, saliva, airway, gastrointestines, genital tracts, Homo sapiens	107	12	34%	1.87	ND

MIC: minimum inhibitory concentration; ND: no data.