. 2023 Jan 8;15(1):216. doi: 10.3390/pharmaceutics15010216

Table 3.

Antibody-functionalized liposomes for anticancer drug delivery.

Lipids	Drug	Ligands	Coupling Method	Cancer Cell (In Vitro)	Cancer (In Vivo)	Ref.
Soya lecithin, Ch, DOPE CHEMS, DSPE–PEG–COOH	Docetaxel	VEGF mAb	Carbodiimide	MCF-7	Breast	[54]
HSPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Afatinib	Cetuximab	Maleimide	A549 H1975	NSCLC	[58]
HSPC, DSPC, Ch, DSPE–PEG DSPE–PEG–maleimide	Simvastatin	Cetuximab	Maleimide	MDA-MB-231	TNBC	[61]
HSPC, Ch (TPGS and TPGS–COOH)	Paclitaxel Piperine	Cetuximab	Carbodiimide	MDA-MB-231 (TNBC)	-	[62]
DSPC, Ch DSPE–PEG–maleimide	5-Fluorouracil	Cetuximab	Maleimide	A431 B16F10	Squamous cell carcinoma	[63]
SPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG–maleimide	Docetaxel	Cetuximab	Maleimide	DU145 PC-3 (prostate)	-	[65]
SPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG–maleimide	Rapamycin	Trastuzumab	Maleimide	MDA-MB-231 SK-BR-3 (breast)	-	[66]
SPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG–maleimide	Rapamycin Paclitaxel	Trastuzumab	Maleimide	4T1 SK-BR-3	Breast	[67]
SPC, Ch DSPE–PEG₂₀₀₀–NHS	Doxorubicin Simvastatin	Trastuzumab	Amine-reactive crosslinker	PC3	Prostate	[68]
Phosphatidylcholine Phosphatidylglycerol Ch, maleimide–PEG	Docetaxel	Trastuzumab	Maleimide	SK-BR-3	Breast	[71]
SPC, Ch, DSPE–PEG DSPE–PEG–maleimide	Idarubicin	Trastuzumab	Maleimide	MCF-7 SK-BR-3 (breast)	-	[73]
DOPE, Ch	Epirubicin	Trastuzumab	Carbodiimide	MCF-7, MDA-MB-453 BT-20 (breast)	-	[74]
Lecithin, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Cisplatin	OX26 mAb	Maleimide	C6	Glioma	[76]
SPC, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Triptolide	CA IX Ab	Maleimide	A549	NSCLC	[79]
DPPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Sepantronium bromide	GD2 Ab	Maleimide	IMR32 KCNR	Neuroblastoma	[81]
HSPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Doxorubicin	scFv G8 Hyb3	Maleimide	MZ2Mel43, G43 Mel2A, Mel78	Melanoma	[83]
HSPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Doxorubicin	PD-L1 mAb	Maleimide	B16-OVA	Melanoma	[84]
Egg phosphatidylcholine DOPE, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Paclitaxel Tariquidar	PD-L1 mAb	Maleimide	SGC7901/ADR	Gastric	[85]
DPPC, Ch, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Paclitaxel	Ab fragment	Maleimide	BxPC3 (pancreatic)	-	[86]
DSPE–PEG₂₀₀₀–maleimide	Doxil^®	Metuximab	Maleimide	Huh-7, HepG2 HCC 3736	HCC	[87]
DSPC, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–maleimide	Timosaponin AIII	CD44 Ab	Maleimide	HepG2	HCC	[88]
DPPC, Ch, mPEG–DSPE DSPE–PEG₂₀₀₀–maleimide	Glycosylated paclitaxel	CD44 mAb	Maleimide	SK-OV-3, OVCAR-3 OVK18	Ovarian	[89]
mPEG₂₀₀₀–DSPE DSPE–PEG₃₄₀₀–NHS	Doxil^®	CD133 mAb	Amine-reactive crosslinker	HT-29 (colorectal)	-	[91]
Ch, Phosphatidylcholine Stearylamine, DSPE–PEG₂₀₀₀ DSPE–PEG₂₀₀₀–COOH	5-Fluorouracil	FZD10 Ab	Carbodiimide	CaCo-2 CoLo-205 (colorectal)	-	[92]

CA, carbonic anhydrase; CD, cluster of differentiation; Ch, cholesterol; CHEMS, cholesteryl hemisuccinate; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DSPC, 1,2-distearoyl-sn-glycero-3-phosphocholine; DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine; FZD10, frizzled 10 protein; GD2, disialoganglioside; HCC, hepatocellular carcinoma; HSPC, hydrogenated soy phosphatidylcholine; NHS, N-hydroxysuccinimide; NSCLC, non-small cell lung cancer; PD-L1, programmed death-ligand 1; PEG, polyethylene glycol; SPC, soy phosphatidylcholine; TNBC, triple-negative breast cancer; TPGS, PEGylated vitamin E succinate; VEGF, vascular endothelial growth factor.