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Mycobacterial replication of M. ulcerans in footpads of B10 mice infected with 105 AFB. Results represent the mean ± SD log10 AFB per milliliter (six mice were tested individually for each time point). Arrows point out different steps during mycobacterial replication in the footpad, i.e., visible swelling or footpad enlargement after 4 weeks and skin ulceration with extensive necrosis of subcutaneous fat after 7 weeks.
