TABLE 1.
Mycobacterial multiplication in unvaccinated and vaccinated B6 mice infected by 3 × 104 or 105 M. ulcerans strain 5150 AFB
| Vaccine | Infection with 3 × 104M. ulcerans AFB
|
Infection with 105M. ulcerans AFB
|
||||||
|---|---|---|---|---|---|---|---|---|
| No. of AFB/mla | ΔLog10b | P valuec | No. of AFB/mla | ΔLog10b | No. of CFU/mla | ΔLog10b | P valuec | |
| None | NDd | 6.16 ± 0.28 (7) | 5.99 ± 0.26 (7) | |||||
| Control DNA | 5.95 ± 0.55 (4) | 5.85 ± 0.25 (6) | 5.63 ± 0.45 (6) | |||||
| M. bovis BCG | 4.60 ± 0.35 (6) | 1.35 | <0.005 | 4.00 ± 0.02 (7) | 1.85 | 4.21 ± 0.14 (7) | 1.42 | <0.005 |
| Ag85A DNA | 4.29 ± 0.42 (5) | 1.66 | <0.005 | 4.71 ± 0.67 (7) | 1.14 | 4.52 ± 0.30 (7) | 1.11 | <0.005 |
a
Mean ± SD of CFU or AFB per milliliter, expressed in log10. The number of mice per group is in parentheses.
b
ΔLog10, difference compared to mice vaccinated with control DNA.
c
Each P value shown reflects a comparison with the mean log10 value for control DNA-treated mice infected with M. ulcerans.
d
ND, not done.