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Chemical structures of selected analogs and binding to JAK2 JH2 and JH1 domains. (a) Diaminotriazole analogs, (b) diaminotriazine analogs, and (c) phenylpyrazolo-pyrimidone analogs. Subgroup R1 marked with yellow, R2 with green and R3 with blue background. Binding data are inhibition-% of tracer binding to recombinant JAK2 JH2 and JH1 domains at 100 µM analog concentration.
