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Differences induced by compound binding to the conformation of Phe594 and Phe595. (a) Comparison of JAK2 JH2 WT (PDB code 4FVQ, green) and JAK2 JH2 V617F (PDB code 4FVR, pink). (b) Comparison of JAK2 JH2 V617F-24 (magenta) and JAK2 JH2 V617F (pink). (c) Comparison of JAK2 JH2 V617F-6 (magenta) and JAK2 JH2 WT (green). (d) Comparison of JAK2 JH2 V617F-16 (magenta) and JAK2 JH2 WT (green).
