Table 1.

The descriptive parameters corresponding to the two incubation times are stated together with their steady-state counterparts. Parameter values for 6 h and 24 h incubation were obtained by fitting two individual hook models (Equation (12)) to the data. Fitting the extended hook model (Equation (14)) to both time points simultaneously allows to estimate the steady-state values. Least squares estimates are reported with the upper and lower bounds of the bootstrap 95% confidence intervals given in brackets. An asterisk (*) indicates that a parameter is significantly different from its steady-state counterpart, according to Welch’s t-test. Experimental data taken from Mares et al. [23].

$\mathit{t} \left(\mathsf{h}\right)$	${\mathit{D}}_{\mathbf{max}} \left(\mathbf{\%}\right)$	$\mathit{D}{\mathit{C}}_{50} \left(\mathrm{nM}\right)$	$\mathit{D}{\mathit{C}}_{\mathbf{max}} \left(\mathrm{nM}\right)$
6	79.8 [73.5, 84.2] *	2.19 [1.41, 5.15] *	79.8 [59.5, 288]
24	95.5 [91.5, 97.2]	0.65 [0.32, 1.46] *	73.7 [48.1, 142]
Steady State	94.9 [93.5, 95.9]	0.29 [0.15, 0.66]	68.9 [47.1, 104]