Figure 4.

Functional implications of the high-affinity SH3^AGS/PRM^Px+P recognitions. (A) Motif-searching to identify the PRM^Px+P-containing proteins and the following Gene Ontology analysis. Two major functions were boxed in red, while other cellular membrane/cytoskeleton-related fields are boxed in blue. (B) A protein–protein interaction network among the SH3^AGS-containing ASAP/GRAF/SKAP proteins (red) and the PRM^Px+P-containing proteins (blue). The known SH3^AGS binding partners were highlighted in dark blue. The targets involving vesicle trafficking and actin cytoskeleton organization are classified with a different color background. (C) A flow chart summarizing the identification of the high-affinity SH3^AGS/PRM^Px+P recognitions and their potential physiological roles.