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. 2023 Jan 10;24(2):1329. doi: 10.3390/ijms24021329

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Graphical representation of DMT’s mechanism of action. DMT is a partial agonist of serotonin receptors (5-HT2) and its mechanism of action involves the second messenger pathway of PLC and A2 in post-synaptic neurons. DMT also acts as an inhibitor of SERT and VMAT2 transporters of serotonin at the pre-synaptic level. On the left of the figure, additional targets of DMT and their intracellular pathways are represented: mGluR2/3, NMDA, sigma-1 receptor and TAARs. Finally, DMT can promote synaptic plasticity by increasing the expression of the transcription factors c-fos, egr-1 and egr-2 and of the neurotrophic factor BDNF. The figure was partly generated using Servier Medical Art, provided by Servier and licensed under a Creative Commons Attribution 3.0 unported license.