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. 2023 Jan 9;24(2):1281. doi: 10.3390/ijms24021281

Figure 1.

Figure 1

Protein cyclization (A) Cyclic Z3 construct map. (B) Schematic representation of SICLOPPS process; The two intein fragments interact to form an active intein that autocatalytically splices to cyclize the flanked Z3 protein by forming a peptide bond and releasing the intein complex.