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. 2022 Dec 21;15(1):21. doi: 10.3390/pharmaceutics15010021

Table 2.

Mechanisms of exosome neuroprotection.

Exosome Sources The Main Molecules Molecules or Pathways Acting in the Process The Main Mechanism Reference
Mesenchymal stem cells (MSC) N/A N/A Increased angiogenesis after ischemia [64]
Adipose-derived MSCs miR-25-3p Autophagy Reduce neuronal autophagy [65]
The astrocyte origin circSHOC2 miR-7670-3p/SIRT1 Inhibition of neuronal cell apoptosis [66]
The astrocyte origin microRNA-34c TLR7, NF-κB/MAPK Reduce ischemia/reperfusion (I/R) injury [67]