Table 3.
KEGG pathway of predicted target genes of the differentially expressed miRNAs. Key pathways have been included in this table.
| miRNA | Pathways | Target Genes | FDR |
|---|---|---|---|
| miR-7-5p | ErbB signaling pathway | CAMK2D, PAK1, RPS6KB1, ERBB4, PRKCB, AKT3, PIK3R3, PIK3CD, RAF1, PAK2, PTK2, EGFR | 1.38 × 10−4 |
| mTOR signaling pathway | RPS6KB1, IRS1, PRKCB, AKT3, DDIT4, PIK3R3, ULK2, PIK3CD, EIF4E | 7.76 × 10−4 | |
| cAMP signaling pathway | CAMK2D, PDE4D, PIK3CD, RRAS2, PIK3R3, ATP2B2, GLI3, RELA, PAK1, GRIN2A, ADCY9, AKT3, PDE4B, PDE4A, RAF1 | 0.001 | |
| Focal adhesion | PRKCB, XIAP, PIK3CD, PIK3R3, PARVA, EGFR, PTK2, IGF1R, PAK1, COL2A1, AKT3, RAF1, PAK2, ITGA9 | 0.004 | |
| Calcium signaling pathway | ITPKC, CAMK2D, GRIN2A, ADCY9, ERBB4, PRKCB, PPIF, VDAC3, VDAC1, ATP2B2, PLCB1, EGFR | 0.009 | |
| Axon guidance | PAK1, DPYSL2, SEMA4C, SLIT1, PLXNA1, NFATC2, SRGAP2, PAK2, PTK2, EPHA3 | 0.009 | |
| miR-15a-5p | PI3K-Akt signaling pathway | CSF1, IRS1, LAMC1, PIK3R1, FGF2, IGF1R, GHR, IKBKB, CCND3, FGF7, RELN, CCND2, FGF9, PPP2R1B, CCND1, YWHAQ, PPP2R1A, AKT3, MYB, EIF4E, YWHAH, MAP2K1, COL24A1, CHUK, INSR, TSC1, PPP2R5C, VEGFA, CDK6, CCNE1, ITGA10, FGF18, BCL2, RAF1, SGK1, SOS2, FGFR1 | 9.43 × 10−4 |
| MAPK signaling pathway | PTPRR, FGF2, CACNA1E, CRKL, ELK4, IKBKB, RPS6KA3, RPS6KA6, FGF7, MAPK8, FGF9, MKNK1, GNA12, AKT3, MAP3K4, MAP2K3, MAP2K1, CHUK, BDNF, CACNA2D1, NFATC3, PPM1A, MRAS, TAOK1, FGF18, NF1, RAF1, SOS2, HSPA1B, FGFR1 | 9.43 × 10−4 | |
| Hippo signaling pathway | YAP1, WNT2B, WNT3A, WWC1, FZD6, WNT7A, AXIN2, AMOT, CCND3, PARD6B, LATS2, CCND2, PPP2R1B, CCND1, YWHAQ, PPP2R1A, BTRC, TEAD1, YWHAH, BMPR1A, WNT4 | 0.001 | |
| Signaling pathways regulating pluripotency of stem cells | MAP2K1, ZFHX3, WNT2B, WNT3A, FZD6, WNT7A, PIK3R1, AXIN2, FGF2, ACVR2B, ACVR2A, IGF1R, AKT3, OTX1, RAF1, JARID2, SKIL, BMPR1A, FGFR1, WNT4 | 0.001 | |
| Neurotrophin signaling pathway | MAP2K1, PRDM4, BDNF, IRS1, FRS2, PIK3R1, CRKL, IKBKB, RPS6KA3, RPS6KA6, MAPK8, IRAK2, ARHGDIA, AKT3, BCL2, RAF1, SOS2 | 0.005 | |
| AMPK signaling pathway | CAB39, IRS1, STRADB, INSR, TSC1, PIK3R1, PPP2R5C, ACACB, FOXO1, IGF1R, RAB10, LIPE, PPP2R1B, CCND1, PPP2R1A, FASN, AKT3 | 0.005 | |
| Wnt signaling pathway | WNT2B, ROCK2, WNT3A, FZD6, SIAH1, NFATC3, WNT7A, AXIN2, NKD1, LRP6, FOSL1, CCND3, MAPK8, CCND2, CCND1, TBL1XR1, BTRC, WNT4 | 0.005 | |
| mTOR signaling pathway | IKBKB, RPS6KA3, RPS6KA6, RRAGA, CAB39, IRS1, AKT3, TSC1, RICTOR, PIK3R1, EIF4E | 0.006 | |
| Rap1 signaling pathway | MAP2K3, MAP2K1, CSF1, INSR, GNAI3, PIK3R1, SIPA1L2, FGF2, ADCY5, CRKL, IGF1R, VEGFA, PARD6B, FGF7, MRAS, ADORA2A, FGF9, RASSF5, GNAQ, AKT3, FGF18, RAF1, FGFR1 | 0.007 | |
| miR-338-3p | MAPK signaling pathway | MAP3K2, MEF2C, PPM1B, CACNB4, MECOM, RASA1, CACNA2D1, MAPK1, GNG12, CRK, DUSP16, FGFR2 | 0.006 |
| miR-424-5p | MAPK signaling pathway | PTPRR, FGF2, CACNA1E, CRKL, ELK4, IKBKB, RPS6KA3, RPS6KA6, FGF7, MAPK8, FGF9, MKNK1, GNA12, AKT3, MAP3K4, MAP2K3, MAP3K3, MAP2K1, BDNF, CACNA2D1, NFATC3, PPM1A, MRAS, TAOK1, FGF18, NF1, RAF1, SOS2, FGFR1 | 0.001 |
| Signaling pathways regulating pluripotency of stem cells | MAP2K1, ZFHX3, WNT2B, WNT3A, FZD6, WNT7A, PIK3R1, AXIN2, FGF2, ACVR2B, ACVR2A, IGF1R, AKT3, OTX1, RAF1, JARID2, SKIL, BMPR1A, FGFR1, WNT4 | 0.001 | |
| PI3K-Akt signaling pathway | IRS1, LAMC1, PIK3R1, FGF2, IGF1R, GHR, IKBKB, CCND3, FGF7, RELN, CCND2, FGF9, PPP2R1B, CCND1, YWHAQ, PPP2R1A, AKT3, MYB, EIF4E, YWHAH, MAP2K1, COL24A1, INSR, TSC1, PPP2R5C, VEGFA, CDK6, CCNE1, ITGA10, FGF18, BCL2, RAF1, SGK1, SOS2, FGFR1 | 0.001 | |
| Neurotrophin signaling pathway | MAP3K3, MAP2K1, PRDM4, BDNF, IRS1, FRS2, PIK3R1, CRKL, IKBKB, RPS6KA3, RPS6KA6, MAPK8, IRAK2, ARHGDIA, AKT3, BCL2, RAF1, SOS2 | 0.001 | |
| Hippo signaling pathway | YAP1, WNT2B, WNT3A, WWC1, FZD6, WNT7A, AXIN2, AMOT, CCND3, PARD6B, LATS2, CCND2, PPP2R1B, CCND1, YWHAQ, PPP2R1A, BTRC, YWHAH, BMPR1A, WNT4 | 0.002 | |
| mTOR signaling pathway | IKBKB, RPS6KA3, RPS6KA6, RRAGA, CAB39, IRS1, AKT3, TSC1, RICTOR, PIK3R1, EIF4E | 0.006 | |
| AMPK signaling pathway | CAB39, IRS1, STRADB, INSR, TSC1, PIK3R1, PPP2R5C, ACACB, IGF1R, RAB10, LIPE, PPP2R1B, CCND1, PPP2R1A, FASN, AKT3 | 0.009 |