Figure 4.

Results of partial least squares (PLS)–SEM analysis with the physio-affective phenome score as the output variable. The latter was entered as a latent vector (blue circle) extracted from six symptom domains (yellow shapes). The phenome latent vector was predicted by calcium, neurotoxicity index, the TO₂ index, and vaccination (AstraZeneca and Pfizer were coded as 0, Sinopharm as 1). SARS-CoV-2 infection was the primary input variable. As such, neurotoxicity and calcium partially mediated the effects of TO₂ and SARS-CoV-2 infection on the physio-affective phenome. Neurotoxicity: z unit-based composite score computed based on six neurotoxic immune and oxidative products. TO₂: z unit-based composite score computed as z BT—z SpO2. Vaccination: indicates that AstraZeneca and Pfizer vaccinations were positively associated with the phenome. PhHAMA: physio-somatic symptoms of the Hamilton Anxiety Rating Scale; PhHAMD: physio-somatic symptoms of the Hamilton Depression Rating Scale; PuFF: pure fatigue and physio-somatic symptoms of the Fibro Fatigue scale; PuHAMA: pure anxiety symptoms of the Hamilton Anxiety Rating Scale; PuHAMD: pure depression symptoms of the Hamilton Depression Rating Scale; PuBDI: pure depression scores from the Beck Depression Inventory. Vaccination: Sinopharm was entered as a dummy variable (yes = 1, no = 0).