Figure 1.

Representation of the DAPC complex in the skeletal muscle. The DAPC complex is a multicomponent system divided into subcomplexes: dystroglycans and sarcoglycans. The cytoplasmic components such as syntrophins and dystrobrevin serve as scaffolds for signalling proteins. AQP4 is localized in the sarcolemma. There are also other signalling molecules (ex. neuronal nitric oxide synthase, nNOS), kinases, ions, etc. Dystrophin, the largest protein in humans, stabilizes the sarcolemma by bridging the cytoskeletal actin to the extracellular matrix (ECM).