Figure 1.

Schematic representation depicting the advantages of combination therapy over monotherapy. Combination therapy includes two or more drugs or immunomodulators with the same or different therapeutic targets. Antiviral combination with different therapeutic activities promotes synergistic action, reducing drug toxicity and drug resistance proportion. The combination of an antiviral and an immune modulator targets virus and host factors, thereby inhibiting virus replication and simultaneously enhancing the host defense mechanism and conferring morbidity and mortality benefits.