Table 2.
Reports of drug mutations and their frequencies in different influenza virus types.
| Influenza Virus Type | Drug | Assay | No. of Tested Isolates | Mutation Percentage | Mutation Detected | Ref. |
|---|---|---|---|---|---|---|
| A & B | Zanamivir | NAI, S | 41 | 0 | - | [74] |
| B | Oseltamivir | NAI, S | 77 | 0 | 1 Gly402Ser | [75] |
| A & B | Oseltamivir | NAI, S | 759 A, 256 B | 2.5% (A-2.5%, 0%-B) | 2 Arg292Lys, 17 His275Tyr | [76] |
| A | Oseltamivir | Cloning + S | 50 | 18% | 1 Asn294Ser,2 Glu119Val, 6 Arg292Lys | [77] |
| A | Oseltamivir | NAI, S | 54 | 4% | 2 His274 Tyr | [78] |
| A | Oseltamivir | PCR | 30 | 15.6% | 4 His275Tyr | [79] |
| A & B | Oseltamivir | NAI, S | 43 A, 19 B | 1.3% (A-1.3%, 0%-B) | 1Arg292Lys, 3 His275Tyr | [80] |
| A | Oseltamivir | NAI, S | 418 | 1% | 1 Glu119Val,4 Arg292Lys | [81] |
| B | Oseltamivir | NAI, S | 74 | 16% | 7 His274Tyr | [82] |
NAI—Neuraminidase Inhibition Assay, S—Sensitivity, and PCR—Polymerase Chain Reaction.