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Effects of HLE on spatial memory impairment of APP/PS1 transgenic mice in the Morris water maze task. (A) Escape latency time of tested mice over 5 days of MWM task acquisition; (B) the swimming time; (C) the crossing numbers; (D) swimming speed in the target zone on the probe test day and (E) path taken by one random rat in each group during MWM probe trial (n = 8). (* p < 0.05, *** p < 0.001, compared with the control (CON) group; # p < 0.05, compared with the APP/PS1 group.)
