TABLE 2.
Cross protection of CBA/N mice immunized with pJB100a
| Challenge strain
|
Median no. of days to death after immunization with:
|
Alive/dead mouse ratio after immunization with:
|
P | ||||
|---|---|---|---|---|---|---|---|
| Name | Capsular serotype | PspA clade | pJB100 | pNGVL3 | pJB100 | pNGVL3 | |
| WU2 | 3 | 2 | >21 | 2.5 | 30:0 | 0:28 | <0.0001 |
| A66 | 3 | 1 or 2 | >21 | 2.0 | 4:0 | 0:4 | <0.02 |
| BDL6A | 6A | 1 | >21 | 6.0 | 10:0 | 1:9 | <0.0001 |
| EF6796 | 6A | 2 | >21 | 9.0 | 6:0 | 1:5 | <0.007 |
| BG9163 | 6B | 2 | >20 | 10 | 13:1 | 3:11 | <0.0003 |
a
Mice were immunized with 10 μg of pJB100 or pNGVL3 (control) and challenged with the indicated strain by i.v. injection on day 35.