Table 4.

Natural product targets 4–12.

No.	Target	E3	Cell Type	Reference
4	AhR	pVHL	Immortalized mouse hepatocyte cells and CV-1 cells (monkey kidney cell line)	[26]
5	CDK9	CRBN	MCF-7 and L02 cells	[30]
6	MDM2	CRBN	RS4;11 cells	[35]
7	MDM2	CRBN	RS4;11, MOLM-13, MDA-MB-468, MV-4-11, HL-60, and MDA-MB-231 cells	[36]
8	MDM2	CRBN	A549, Huh7, and HepG2 cells	[37]
9	HDAC6	CRBN	K562, HeLa, and THP-1 cells	[38]
10	STAT3	CRBN and VHL	CAL33 and HCT116 cells	[39]
11	Hemagglutinin protein	CRBN and VHL	Human embryonic kidney 293T cells	[40]
12	MAFF	CRBN	Mouse RAW264.7 macrophage and human embryonic kidney 293T (HEK293T) cells	[42]