Table 2.
AT(N) profiles and their associations with demographic and clinical variables.
| Normal AT(N) (n = 134) |
SNAP AT(N) (n = 88) |
Brain Amyloidosis AT(N) (n = 72) |
Prodromal AD AT(N) (n = 206) |
p Value | |
|---|---|---|---|---|---|
| Age (y) | 70.18 (8.73) | 73.94 (7.1) | 72.94 (7.34) | 75.18 (6.08) | <0.001 |
| Female sex (%) | 52.2 | 55.7 | 54.2 | 56.3 | 0.900 |
| Education (y) | 7.69 (3.76) | 7.01 (4.19) | 8.25 (7.53) | 8.15 (4.43) | 0.246 |
| Amnestic MCI | 73.1 | 84.1 | 79.2 | 89.3 | 0.001 |
| Probable MCI | 23.9 | 43.2 | 33.3 | 55.8 | <0.001 |
| MMSE score | 26.09 (3.11) | 25.42 (3.51) | 25.56 (3.90) | 25 (3.22) | 0.026 |
| APOE ε4 carrier | 11.2 | 31.8 | 30.6 | 56.8 | <0.001 |
| NPS | |||||
| Depression | 53 | 56.8 | 50 | 46.1 | 0.344 |
| Anxiety | 47 | 48.9 | 44.4 | 38.8 | 0.314 |
| Apathy | 40.3 | 31.8 | 40.3 | 37.4 | 0.595 |
| Irritability/lability | 37.3 | 33 | 33.3 | 35.9 | 0.896 |
| Nighttime Behaviors | 24.6 | 23.9 | 27.8 | 14.1 | 0.023 |
AD: Alzheimer’s disease; APOE: apolipoprotein E; MCI: mild cognitive impairment; MMSE: Mini-Mental State Examination; NPSs: Neuropsychiatric Symptoms; SNAP: Suspected Non-Alzheimer’s Pathology; y: years.