Table 3.
NPS and their association with demographic and clinical variables.
| Depression (yes = 252/ no = 248) |
Anxiety (yes = 218/ no = 282) |
Apathy (yes = 188/ no = 312) |
Irritability/Lability (yes = 177/no = 323) |
Nighttime Behaviors (yes = 103/ no = 397) |
|
|---|---|---|---|---|---|
| Female sex | 65.1/44.4 ** | 65.1/46.1 ** | 50/57.7 | 40.1/62.8 ** | 62.1/52.9 |
| Age (y) | 72.29 (7.6)/ 74.33 (7.23) |
72.62 (7.77)/ 73.82 (7.22) |
72.49 (7.19)/ 73.79 (79) |
73.31 (7.26)/ 73.3 (7.61) |
72.81 (7.59)/ 73.43 (7.46) |
| Education (y) | 7.66 (5.13)/ 8.02 (4.42) |
7.5 (5.37)/ 8.11 (4.29) |
7.63 (4.22)/ 7.96 (5.11) |
8.32 (4.32)/ 7.58 (5.02) |
8.07 (6.55)/ 7.78 (4.23) |
| Amnestic MCI | 79/86.1 * | 80.7/84 | 88.3/79.2 * | 85.3/81.1 | 83.5/82.4 |
| Probable MCI | 49.6/34.1 ** | 31.2/50 ** | 43.1/41 | 44.1/40.6 | 33/44.1 |
| MMSE score | 25.35 (3.18)/ 25.54 (3.31) |
25.44 (3.08)/ 25.45 (3.37) |
25.45 (3.19)/ 25.44 (3.28) |
25.64 (2.96)/ 25.34 (3.339) |
25.4 (3.28)/ 25.62 (3.14) |
| APOE ε4 carrier | 39.1/33.7 | 36.7/36.1 | 36.7/36.2 | 41.2/33.7 | 38.8/35.8 |
| AT(N) profiles | |||||
| Normal | 28.2/25.4 | 28.9/25.2 | 28,7/25.6 | 28.2/26 | 32/25.4 |
| SNAP | 19.8/15.3 | 19.7/16 | 14.9/19.2 | 16.4/18.3 | 20.4/16.9 |
| Brain Amyloidosis | 14.3/14.5 | 14.7/14.2 | 15.4/13.8 | 13.6/14.9 | 19.4/13.1 |
| Prodromal AD | 37.7/44.8 | 36.7/44.7 | 41/41.3 | 41.8/40.9 | 28.2/44.6 * |
* p < 0.05; ** p < 0.001. AD: Alzheimer’s disease; APOE: Apolipoprotein E; MCI: Mild Cognitive Impairment; MMSE: Mini-Mental State Examination; NPSs: Neuropsychiatric Symptoms; SNAP: Suspected Non-Alzheimer’s Pathology; y: years.