Table 4.
Demographic and clinical overview of MCI non-converters vs. MCI converters.
| MCI Non-Converters (n = 276) |
MCI Converters (n = 224) |
t or Chi Statistics | p Value | |
|---|---|---|---|---|
| Female sex (%) | 53.3 | 56.7 | 0.589 | 0.443 |
| Age (y) | 71.72 (7.91) | 75.24 (6.42) | 5.49 | <0.001 |
| Education (y) | 7.43 (5.52) | 8.17 (4.09) | 1.71 | 0.098 |
| Amnestic MCI (%) | 72.1 | 95.5 | 47.25 | <0.001 |
| Probable MCI (%) | 31.2 | 54.9 | 28.67 | <0.001 |
| MMSE score | 26.38 (2.81) | 24.3 (3.38) | 7.49 | <0.001 |
| APOE ε4 carrier (%) | 29.7 | 44.6 | 11.91 | 0.001 |
| Time follow-up (y) | 2.51 (1.22) | 1.51 (.93) | 9.92 | <0.001 |
| AT(N) profiles (%) | ||||
| Normal | 39.1 | 11.6 | ||
| SNAP | 20.3 | 14.3 | ||
| Brain Amyloidosis | 14.5 | 14.3 | ||
| Prodromal AD | 26.1 | 59.8 | 71.64 | <0.001 |
| NPS (%) | ||||
| Depression | 48.2 | 53.1 | 1.21 | 0.272 |
| Anxiety | 42.4 | 45.1 | 0.366 | 0.545 |
| Apathy | 33.3 | 42.9 | 4.78 | 0.029 |
| Irritability/Lability | 34.1 | 37.1 | 0.485 | 0.486 |
| Nighttime Behaviors | 21.7 | 19.2 | 0.489 | 0.484 |
AD: Alzheimer’s disease; APOE: Apolipoprotein E; MCI: Mild Cognitive Impairment; MMSE: Mini-Mental State Examination; NPSs: Neuropsychiatric Symptoms; SNAP: Suspected Non-Alzheimer’s Pathology; y: years.