Table 5.
Cox regression analysis for AT(N) profiles, NPSs and adjusting factors.
| Hazard Ratio (HR) | z | 95% CI HR | p-Value | |
|---|---|---|---|---|
| AT(N) profiles | ||||
| SNAP | 1.79 | 2.11 | 1.04–3.06 | 0.035 |
| Brain Amyloidosis | 2.92 | 3.96 | 1.72–4.97 | <0.001 |
| Prodromal AD | 4.34 | 6.19 | 2.72–6.91 | <0.001 |
| NPS | ||||
| Depression | 1.47 | 2.36 | 1.06–2.2 | 0.019 |
| Anxiety | 1.04 | 0.23 | 0.76–1.4 | 0.820 |
| Apathy | 1.4 | 2.32 | 1.05–1.86 | 0.020 |
| Irritability/Lability | 0.99 | 0.05 | 0.73–1.33 | 0.958 |
| Nighttime Behaviors | 0.86 | 0.84 | 0.59–1.22 | 0.403 |
| Female sex | 0.83 | 1.19 | 0.61–1.12 | 0.235 |
| Age (y) | 1.02 | 2.14 | 1.01–1.04 | 0.033 |
| Education (y) | 1.00 | 0.32 | 0.98–1.03 | 0.747 |
| Amnestic MCI | 3.63 | 3.88 | 1.89–6.67 | <0.001 |
| Probable MCI | 1.51 | 2.75 | 1.12–2.02 | 0.006 |
| MMSE score | 0.87 | 6.22 | 0.83–0.91 | <0.001 |
| APOE ε4 carrier | 0.98 | 0.12 | 0.73–1.31 | 0.904 |
For AT(N) profiles, the Normal group is the reference category. AD: Alzheimer’s Disease; APOE: Apolipoprotein E; CI: Confidence Interval; MCI: Mild Cognitive Impairment; MMSE: Mini-Mental State Examination; NPSs: Neuropsychiatric Symptoms; SNAP: Suspected Non-Alzheimer’s Pathology; y: years.