Table 6.
Additive and multiplicative interactions in Cox regression analysis for ATN and NPSs.
| Additive Interactions | Multiplicative Interactions | |||||
|---|---|---|---|---|---|---|
| Coeff. | 95% CI Coeff. | p | Coeff. | 95% CI Coeff. | p | |
| AT(N)*Depression | 3.23 | 0.20–6.26 | 0.037 | 0.023 | −0.84–0.88 | 0.958 |
| AT(N)*Anxiety | 1.63 | −0.01–3.28 | 0.051 | 1.73 | 0.72/4.13 | 0.213 |
| AT(N)*Apathy | 1.33 | −0.99/3.66 | 0.260 | 0.86 | 0.36/2.02 | 0.735 |
| AT(N)*Irritability/Lability | 0.81 | −1.30/1.87 | 0.728 | 1.27 | 0.52/3.11 | 0.591 |
| AT(N)*Nighttime Behaviors | −2.24 | −5.43/0.94 | 0.167 | 0.36 | 0.13/0.94 | 0.034 |
Additive and multiplicative interactions are calculated contrasting normal AT(N) and prodromal AD AT(N) groups. Results are adjusted by age, sex, years of education, amnestic profile (yes/no), probable MCI (yes/no) APOE ε4 carrier (yes/no) and MMSE at baseline.