Table 1.
Examples of extracellular proteases produced by selected fungi that are pathogenic for humans.
| Fungal Species | Identified Proteases | Protease Classification |
|---|---|---|
| Candida spp. | ||
| C. albicans | Sap1-Sap10 | aspartic proteases |
| C. glabrata | yapsins (CgYps1-11) |
aspartic proteases |
| C. parapsilosis | Sapp1, Sapp2 | aspartic proteases |
| Aspergillus spp. | ||
| secreted subtilisins (i.e., Alp1/Asp f 13) | serine proteases | |
| elastinolytic proteases Mep, fungalysins (i.e., Asp f 5) |
metalloproteases | |
| secreted aspartyl endopeptidase (i.e., aspergillopepsin-1/ Asp f 10) |
aspartic proteases | |
| protease PnmB | serine protease | |
| Penicillium spp. | ||
| secreted subtilisin-like proteases (i.e., Pen c 13, Pen ch 13) |
serine proteases | |
| Cryptococcus neoformans | ||
| major aspartyl peptidase 1 May1 | aspartic protease | |
| endopeptidase Prb1 | serine protease | |
| secreted metalloprotease Mpr1 | metalloprotease | |
| Pneumocystis jiroveci | kexin (Kex1) | serine protease |
| Rhizopus oryzae | rhizopuspepsin, Rhi o 1 | aspartic protease |
| Malassezia furfur | secretory aspartyl protease Mfsap1 | aspartic protease |
| Dermatophytes | ||
| secreted subtilisins (Sub2–Sub7) |
serine proteases | |
| fungalysins (Mep1, Mep3, Mep4) |
metalloproteases | |
| dipeptidyl peptidases (DppIV, DppV) | serine exoproteases | |
| Endemic fungi | ||
| Paracoccidioides brasiliensis | extracellular subtilisin-like protease (PbSP) | serine protease |
| Histoplasma capsulatum | N-acetylated α-linked acidic dipeptidase (NAALADase) | metallocarboxypeptidase |
| Sporothrix schenckii | proteinase I | serine protease |
| proteinase II | cysteine protease |