Figure 2.

Comorbidity burden and their temporal relations in patients with onychomycosis. All disease pairs illustrated in the figure are overrepresented in patients with onychomycosis compared to controls without onychomycosis. The disease pairs represent a minimum of 50 patients. Thus, the figure illustrates that patients with onychomycosis treated in Danish hospitals often have cardiovascular diseases prior to complications of the first disease, e.g., essential hypertension prior to heart failure and acute myocardial infarction prior to chronic ischemic heart disease prior to pneumonia and respiratory failure. Interestingly, the only diseases occurring in a minimum of 50 patients with onychomycosis are mental disorders due to the consumption of alcohol (green dot); muscle disorders (dark red dot); and excessive, frequent, and irregular menstruation (yellow dot). The different chapters in the 10th version of the International Classification of Disease are illustrated by various colors and Roman numerals.