Table 1.

A summary of methods that increase and decrease NF-κB activity. As well some of the mediators of NF-κB’s activity. In addition, some of the effects of NF-κB towards M. tb infection.

Summary of the Role of NF-κB during M. tb Infection
Cause and effect of increased NF-κB and its enzymes	Cause and effect of decreased NF-κB and its enzymes
-An increase in NF-κB to a certain unknown level has been shown to be effective as an anti-inflammatory mediator to assist in the fight against tuberculosis -NF-κB increases IL-2R production and thus reduces the lymphocytic response towards M. tb, thus a substantial increase in NF-κB has been shown to increase the survival of M. tb -Triple therapy of INH, RIF, PYZ has been shown to be the most effective combination of anti-tb drugs to increase NF-κB -The activation of TNFR1 activates IκB kinase which phosphorylates IκB proteins to release free NF-κB	-INH, RIF, PYZ administered individually seem to decrease NF-κB activity -Decreased NF-κB has been shown to allow increased M. tb survival -NF-κB remains inactive by being bound to IκB proteins -IκBα and A20 reduce TNFR1 activity, which, in turn, reduce IκB kinase and subsequently reduce free NF-κB