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The role of TRPV3 in itch signal and cell proliferation. ERK, extracellular signal-regulated kinase; ADAM17, metalloprotease ADAM17; DAG, diacylglycerol; IP3, inositol trisphosphate; PIP2, phosphatidylinositol(4,5)bisphosphate; PLC, phospholipase C; CNS, central nervous system; TSLP, thymic stromal lymphopoietin [34].
