Table 1.
TRPV3 and diseases.
| Diseases | Research Evidence | Reference(s) |
|---|---|---|
| Olmsted syndrome (OS) |
A series of independent clinical reports are identified mutations in the TRPV3 gene as the cause of Olmsted’s syndrome. | [37,38,39,40,41,42] |
| Pruritic and atopic dermatitis (AD) |
1. The expression of TRPV3 is significantly increased in skin lesions and non-diseased skin of patients with specific dermatitis. 2. The pharmacological activation of TRPV3 leads to the development of AD in wild-type mice, and it has no effect on TRPV3 knockout mice. 3. The inhibition of TRPV3 treats inflammatory dorsal skin in a dose-dependent manner. | [43,44,45] |
| Psoriasis | 1. The expression level of TRPV3 in psoriasis patients is significantly higher than it is in people without psoriasis. 2. TRPV3 antagonists relieve the symptoms in patients with moderate-to-severe psoriasis in a dose-dependent manner. | [46] |
| Cutaneous pruritus |
1. TRPV3 knockout mice show no increase in scratching behavior after itch modeling. 2. The expression of TRPV3 is significantly up-regulated in the epidermis of patients with pruritus after having been burnt. | [47,48] |
| Rosacea | TRPV3 gene expression is significantly increased in rosacea. | [49] |
| Cancer | 1. TRPV3 expression is increased in pancreatic, bone, breast, lung and oral squamous cell cancers. 2. TRPV3 expression is decreased in colorectal cancer. | [21,50,51,52] |
| Myocardial hypertrophy |
1. The expression of TRPV3 is increased in pathological cardiac hypertrophy. 2. TRPV3 expression is increased in cardiomyocyte hypertrophy induced by Ang-II in vitro. 3. TRPV3 inhibitors can significantly aggravate cardiomyocyte hypertrophy and TRPV3 antagonists can slow cardiomyocyte hypertrophy. | [53] |
| Cardiac fibrosis | TRPV3 activation exacerbate cardiac dysfunction and interstitial fibrosis in pressure-overloaded rats. | [54] |
| Myocardial infarction |
The expression of TRPV3 is significantly up-regulated in neonatal rat cardiomyocytes after myocardial infarction and in hypoxia-treated rats. | [55] |
| Pain | TRPV3 is overexpressed in skin pain, breast pain, cancer pain and other pain-experiencing tissues. | [56,57,58] |
| Alopecia | TRPV3 agonists inhibit hair growth, whereas TRPV3 inhibitors significantly reverse the symptom. | [59] |