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. 2023 Jan 5;24(2):1053. doi: 10.3390/ijms24021053
4T1 Mouse breast cancer cells
9-AC 9-Aminocamptothecin
9-CPT Rubitecan
9-NC 9-Nitrocamptothecin
A2780sn Human ovarian cancer cell line
A549 Human lung carcinoma cell line
ALL Acute lymphocytic leukemia
AML Acute myelogenous leukemia
AUC Area under the curve
BAX Bcl-2-associated X protein
BEL-7402 Human hepatoma cell line
Caco-2 Colorectal adenocarcinoma cell line
CD123 Interleukin-3 receptor alpha chain
CD147 mAb CD147 monoclonal antibody
CKD-602 Belotecan
CL ε-Caprolactone
Cmax Highest concentration of the drug
COLO-205 Human colon carcinoma cell line
CPPs Cell penetrating peptides
CPT Camptothecin
CPT-11 Irinotecan
CT26 Mouse colorectal carcinoma cell line
CuAAC Cu(I)-catalyzed azidealkyne cycloaddition
Da Dalton
DDSs Drug delivery systems
DX-8951f Exatecan
EE Entrapment efficiency
EGDMA Ethylene glycol dimethacrylate
FDA US Food and Drug Administration
FGF3 Fibroblast growth factor 3 gene
FOL Folate
GG-211 Lurtotecan
GSH Glutathione
GA Glycolide monomer
H22 Hepatocellular carcinoma cell line
HCT116 Human colon cancer cell line
Hep3B Human hepatoma cell line
HepG2 Human hepatocellular carcinoma cells
HGC27 Gastric cancer cells
HGG High-grade glioma
HIST Histone cluster 1 gene
HMW High molecular weight
HT-29 Human colorectal adenocarcinoma cell culture
IC50 Drug concentration needed to inhibit 50% of the cell growth
IRH
LA
Irinotecan hydrochloride trihydrate
Lactide monomer
LMW Low molecular weight
mAB Monoclonal antibodies
MC3T3 Mouse osteoblast cell line
Mn Number-averaged molecular weight
Mw Weight-averaged molecular weight
mPEG Monomethoxy-poly(ethylene glycol)
MPEG-P(CL-ran-TMC) Monomethyl poly(ethylene glycol)-poly-(ε-caprolactone)-poly(trimethylene carbonate)
mPEG-PLA Methoxypoly(ethylene glycol)-b-poly(lactide)
MRT Mean residence time
MTD Maximum tolerated dose
MX-1 Human mammary carcinoma cell line
NPs Nanoparticles
NX-211 Liposomal lurtotecan
OSI-211 Liposomal lurtotecan
OVCAR 3 Human ovarian carcinoma cell line
P(EAEP-PPA) Poly(ethyl-bis(2-(acryloxy)ethyl phosphate-co-2-propynylamine)
Panc-1 Human pancreatic cancer cell line
PARP Poly adenosine diphosphate-ribose polymerase
PBS Phosphate buffer solution
PCL Poly(ε-caprolactone)
PDCs Polymer–drug conjugates
PDLLA Poly(D,L-lactide)
PEG Poly(ethylene glycol)
PGA Poly(glycolide), Poly(glycolic acid)
PGACL Poly(glycolide-co-ε-caprolactone)
PHB Poly(3-hydroxybutyrate)
PHF Poly(1-hydroxymethylethylene hydroxy-methyl formal)
PLA Polylactide
PLACL Poly(lactide-co-ε-caprolactone)
PLGA Poly(lactide-co-glycolide)
PDLA Poly(D-lactide)
PLLA Poly(L-lactide)
rac-LA A racemic mixture of L-LA and D-LA
RAFT Reversible addition fragmentation transfer
RGCC Regulator of cell cycle, response gene to complement 32 protein
ROMP Ring-opening metathesis polymerization
ROP Ring-opening polymerization
S-180 Sarcoma bearing Kunming mice
SAR Structure–activity relationship
sc-PLA Stereocomplex PLA
SKOV3 Human ovarian cancer cell line
SMPs SN-38-loaded biodegradable PLGA microparticles
SN-38 7-Ethyl-10-hydroxycamptothecin
SN-38-BOC 7-Ethyl-10-O-tert-butyl ester-camptothecin
SW-480 Human colon adenocarcinoma cell line
SW1990 Human pancreatic cell line
SW620 Human colon tumor
TGI Tumor growth inhibition
THP-1 Human acute myeloid leukemia cell line
Tmax Time to reach maximum concentration of the drug
TMC Trimethylene carbonate
TMC N-Trimethyl chitosan chloride
Top 1 Topoisomerase I
UBD Ubiquitin D gene
UV Ultraviolet
Vss Volume of distribution at steady stage
WBC White blood cell
ζ Zeta potential