Figure A1.

Multivariable mixed-effects models for explanatory variables (fixed effects) of severe COVID-19 (a) and in-hospital death (b) among hospitalized COVID-19 patients, COVID-19 clinical hospital surveillance. The following fixed effects were retained in the models obtained after stepwise backward elimination of non-significant (p < 0.05) variables: vaccination status (primary vaccination course compared to unvaccinated), age (years), sex (male compared to female), nursing home residency, obesity, hematological cancer, chronic lung disease, and mean ICU occupancy rate (%). For the outcome severe COVID-19 (a), solid organ transplantation was additionally retained and for in-hospital death (b) additionally cognitive disease was retained. Hospital was added as a random effect to the model. ICU = intensive care unit. * p < 0.05, ** p < 0.01, *** p < 0.001.