Figure 5.

Schematic illustration of MAG or Nogo-A signaling cascades in the pathology of cerebral ischemia. The overproduction of Myelin-associated glycoprotein (MAG) Neurite outgrowth inhibition protein-A (Nogo-A) after cerebral ischemia activates the signaling cascades linked to the RhoA/ROCK pathway, which collapses neuronal growth cones and inhibits axonal growth. Such inhibitory events significantly suppress the functional recovery after the suffering of cerebral ischemia. Inhibition of the MAG or Nogo-A with highly specific antibody-based therapeutics can enhance the axonal regeneration and neurite outgrowth dramatically, which leads to better functional recovery after cerebral ischemia.