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Relative efficacy, therapeutic index and lethal dose for selected synthetic opioids (according to different sources) [65].
| Compound | Relative Efficacy | Therapeutic Index | LD50 (Rat, i.v.), mg/kg |
|---|---|---|---|
| Morphine (standard) | 1 | 70 | <200 |
| Methadone | 4 | 12 | Not known |
| Alfentanil | 75 | 1100 | 47.5 |
| Remifentanil | 220 | 33,000 | Not known |
| Fentanyl | 300 | 300 | 3.5 |
| Sufentanil | 4500 | 25,000 | 17.9 |
| Carfentanil | Up to 10,000 | 10,600 | 3.4 |
