Figure 2.

Role of intracellular and extracellular S100A6 in Ca²⁺-cellular signaling. Increased intracellular Ca²⁺ level induces a conformational change of S100A6 molecule, which enables it to interact with various intracellular proteins or, following secretion, to bind to receptor proteins and activate signaling pathways and, ultimately, gene transcription that leads to cell survival/proliferation. TF—transcription factor.