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Effects of PRRSV-infected PTR2 cells (MOI = 1) on the transcription of GPER1 genes under estrogen (E2)-stimulated and unstimulated conditions (A). Effects of PRRSV infection on PTR2 cells (MOI = 1) on GPER1 protein expression, and the effects of different concentrations of estrogen on PRRSV replication (B). Effects of PRRSV in different doses infecting PTR2 cells on the estrogen-induced activation of the PI3K-AKT-mTOR signaling pathway (C). *** p < 0.001.
