Figure 8.

The interaction between the differentially expressed mRNAs and lncRNAs associated with apoptosis in the PTR2 cells infected with PRRSV. Network analysis provides a global view of all the possible lncRNA- mRNA expression associations based on the different upstream targets of apoptosis backgrounds (A) and downstream targets of apoptosis backgrounds (B) in the PRRSV-infected PTR2 cells. Upstream targets of mRNAs include TRAF2, NFKB1, RELA, PIK3R1, and IRAK3. Downstream targets of mRNAs include CYCS, BCL2L1, CASP6, CASP7, CASP9, and CASP10. Other targets are lncRNAs, which are predicted to regulate mRNA expression. The arrows represent mRNAs and the ellipses represent lncRNAs. Blue means up-regulation, green means down-regulation.