Figure 5.
The potency of Ms11a-3 on various nAChR subtypes of some animal species. (A–E), represent 1 μM and 10 μM concentrations of Ms11a-3 selectively block nAChR subtypes. Control indicates responses to ACh without incubation with Ms11a-3. (F). Dose-response curves for the peptide Ms11a-3 at most sensible nAChR subtypes. Each point presented on the dose-response curve was shown as mean ± SEM analyzed from parallel data of 3–6 oocytes. Species’ origin of receptors is rat (r), mouse (m) and human (h). The respective calculated IC50 and Hill slope are shown in Table 2.