Table 1.
The most common chromosomal alterations and associated genes involved in adenoma to carcinoma progression.
| CNVs | Associated Gene | Reference | |
|---|---|---|---|
| Gain | 7p | EGFR | [11] |
| Gain | 8q | c-MYC | [10,16,17] |
| LYN | [13] | ||
| Gain | 13q | CDX2 | [10,16,17] |
| POLR1D | [13] | ||
| PDX1 | [11] | ||
| Gain | 20q | AURKA | [13,14] |
| TH1L | [14] | ||
| ADRM1 | [14] | ||
| C20orf20 | [14] | ||
| TCFL5 | [14] | ||
| TPX2 | [25] | ||
| PMPEA1 | [13] | ||
| MMP9 | [13] | ||
| MYBL2 | [13,39] | ||
| UBE2C | [13] | ||
| Loss | 1p | [11] | |
| Loss | 3p | FHIT | [30] |
| Loss | 4p | [30] | |
| Loss | 5p | [31] | |
| Loss | 8p | CSMD | [13] |
| DLC1 | [10,16] | ||
| Loss | 14q | [13] | |
| Loss | 15q | [10] | |
| Loss | 17p | TP53 | [10] |
| Loss | 18q | DCC | [12] |
| SMAD2 | [12] | ||
| SMAD4 | [12] | ||
| CCDC68 | [13] | ||
| SERPINB7 | [39] | ||
| CTDP1 | [39] | ||
| Loss | 20p | [13] |