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R5 (Central obstruction: (A) total follow-up; (B) follow-up of expected nicotine half-life). The central obstruction is displayed over time. The first (time 5) and second (time 15) measurements after the intervention Cig, E-Cig (+) and E-Cig (-) show a significant (* p < 0.05) increase. The Chewing bag stays at resting levels.
