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. 2023 Jan 4;24(2):984. doi: 10.3390/ijms24020984

Table 1.

The results of the analysis of association between the studied genetic variants and type 2 diabetes in the study group.

Chr 1 Position
GRCh37 2 		Gene SNP 3 EA 4 MA 5 MAF 6 PHWE 7 OR 8 (95% CIOR) 9 P 10 PFDR 11
Control T2D
1 66,036,441 LEPR rs1137100 G G 0.28 0.31 0.429 1.24 (0.89–1.72) 0.202 0.348
2 228,677,842 CCL20 rs6749704 * C C 0.28 0.39 0.094 1.68 (1.35–2.09) 2.61 × 10−6 3.40 × 10−5
3 39,307,162 CX3CR1 rs3732378 A A 0.21 0.21 0.092 1.01 (0.77–1.31) 0.954 0.954
3 46,414,944 CCR5 rs333 * D D 0.06 0.10 1.000 1.99 (1.16–3.42) 0.013 0.033
3 186,572,089 ADIPOQ rs17366743 * C C 0.03 0.09 1.000 3.17 (1.64–6.12) 6.10 × 10−4 2.64 × 10−3
8 19,819,077 LPL rs320 G G 0.24 0.26 0.294 1.21 (0.90–1.62) 0.214 0.348
10 114,758,349 TCF7L2 rs7903146 * T T 0.25 0.39 0.616 1.77 (1.37–2.29) 1.44 × 10−5 9.37 × 10−5
11 68,201,295 LRP5 rs3736228 T T 0.10 0.12 0.490 0.97 (0.64–1.46) 0.874 0.947
12 14,018,777 GRIN2B rs7301328 G C 0.43 0.40 0.103 1.16 (0.95–1.41) 0.150 0.325
16 57,447,414 CCL17 rs223828 C T 0.14 0.12 1.000 1.20 (0.86–1.65) 0.280 0.405
17 32,579,788 CCL2 rs1024611 * A G 0.31 0.24 0.627 1.38 (1.08–1.76) 0.011 0.033
17 32,612,402 CCL11 rs16969415 T T 0.06 0.06 1.000 1.13 (0.74–1.74) 0.565 0.734
17 34,207,780 CCL5 rs2107538 C T 0.25 0.25 0.261 0.95 (0.73–1.22) 0.662 0.783

1 Chr—chromosome, 2 GRCh37—Genome Reference Consortium Human Build 37; 3 SNP—single nucleotide polymorphism; 4 EA—effect allele; 5 MA—minor allele; 6 MAF—minor allele frequency; 7 PHWE—level of significance for the Hardy-Weinberg procedure; 8 OR—odds ratio; 9 95%CIOR—95% confidence interval for the odds ratio; 10 p—level of significance; 11 PFDR—level of significance with the Benjamini–Hochberg adjustment. * The variants significantly associated with the type 2 diabetes genetics after the correction for multiple testing are denoted by an asterisk.