Table A6.

Calculations for ERIG, HRIG & R-Mab for Scenario Analysis.

Amount Calculations for RIG (Scenario Analysis)
	ERIG (Base Case)	ERIGLocal Only (Scenario 1)	HRIG (Scenario 2)	R-Mab (Scenario 3)
Vial	5 mL	5 mL	2 mL	2.5 mL
Discounted cost per vial (INR)	195.66	195.66	2312.84	1231.43
Potency (per mL)	300 IU/mL	300 IU/mL	150 IU/mL	40 IU/mL
Potency (per vial)	1500 IU/vial	1500 IU/vial	300 IU/vial	100 IU/vial
Dose	40 IU/kg wt	40 IU/kg wt	20 IU/kg wt	3.33 IU/kg wt
	1 mL = 300 IU	1 mL = 300 IU	1 mL = 150 IU	1 mL = 40 IU
Maximum dose calculation	Dose = 40 U × 32.47= 1298.8 IU		Dose = 20 IU × 32.47= 649.4 IU	Dose = 3.33 IU × 32.47 = 108.13 IU
(Weighted proportionate weight for cohort)	Amount = 1298.8/300 mL		Amount = 649.4/150 mL	Amount = 39.1/40 mL
	Amount = 4.33 mL	Amount = 2.64 mL [33]	Amount = 4.33 mL	Amount = 2.7 mL
Amount of RIG required in children	4.33 mL	2.64 mL	4.33 mL	2.7 mL
Multiplication factor for use from a vial	4.33/5 = 0.866	2.64/5 = 0.528	4.33/2 = 2.165	2.7/2.5 = 1.08