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. 2023 Jan 6;24(2):1118. doi: 10.3390/ijms24021118

Figure 1.

Figure 1

Intratumoral and systemic neutrophil extracellular trap (NET) formation correlates with poor prognoses in colorectal cancer (CRC) patients. (A) Hematoxylin and eosin staining (H&E) and immunohistochemical (IHC) staining for myeloperoxidase (MPO), citrullinated histon H3 (Cit-H3), matrix metalloproteinase 9 (MMP9) and neutrophil elastase (NE) in primary CRC specimens. Upper and lower panels show serial sections of representative high and low expression of Cit-H3 in CRC specimens, respectively. Scale bars, 500 μm. Magnified images are shown in right upper quadrant. Scale bars, 100 μm. (B) Effects of Cit-H3 expression on relapse-free survival (RFS) (right) and overall survival (OS) (left) in patients who underwent curative resection of stage I–III CRC (Kaplan–Meier estimates). p values were calculated using the log-rank test. (C) Effects of preoperative serum MPO–DNA levels on RFS (right) and OS (right) in patients who underwent curative resection of stage II and III CRC (Kaplan–Meier estimates). p values were calculated using the log-rank test.