Table 1.

Univariate and multivariate analysis using clinicopathological characteristics and Cit-H3 expression for RFS in 133 CRC patients.

Variables	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p	HR	95% CI	p
Age, years (<68 vs. ≥68)	1.02	0.48–2.17	0.96
Sex (male vs. female)	0.57	0.24–1.35	0.2
Location (colon vs. rectum)	1.99	0.95–4.19	0.069	1.71	0.75–3.92	0.2
T factor (Tis-T2 vs. T3-T4)	1.99	0.76–5.24	0.16
n factor (negative vs. positive)	4.86	2.2–10.77	< 0.0001	3.26	1.38–7.70	0.0071
Lymphatic invasion (ly0 vs. ≥ly1)	3.69	1.67–8.17	0.0013	2.01	0.84–4.80	0.12
Venous invasion (v0 vs. ≥v1)	2.03	0.92–4.48	0.08	1.33	0.57–3.08	0.51
Preoperative therapy (no vs. yes)	4.68	1.77–12.37	0.0019	2.04	0.67–6.21	0.21
Adjuvant therapy (no vs. yes)	1.35	0.64–2.84	0.43
NLR (<3 vs. ≥3)	1.05	0.47–2.32	0.91
CEA (ng/mL, <5 vs. ≥5)	1.34	0.63–2.81	0.44
CA19-9 (U/mL, <37 vs. ≥37)	1.94	0.73–5.11	0.21
Cit-H3 expression (low vs. high)	2.86	1.26–6.49	0.012	2.86	1.25–6.54	0.013

NLR, neutrophil lymphocyte ratio; CEA, carcinoembrionic antigen; CA19-9, carbohydrate antigen 19-9; HR, hazard ratio; CI, confidence interval.