Figure 6.

The activity of MMP-2 and MMP-9 in the culture media from fibroblasts treated with various concentrations of rhPEPD (10, 50 nM), IL-1β (10 ng/mL) and gefitinib (45 µM) for 24 h (A) and respective quantification analysis done by densitometry (B). The mean values ± S.D. of three experiments carried out in duplicate are presented. The results are significant at p < 0.05, represented by ^ and *; ^ indicates significance vs. control (0 nM of PEPD without IL-1β for MMP-9), and * indicates significance vs. control (0 nM of PEPD without IL-1β for MMP-2).