Figure 7.
The preliminary data indicated the most promising structure for further research. Panel (A) presents the cytotoxic effects of compounds 4, 5, 7, 8, 10, and 13 after treatment lasting 24 h, while panel (B) presents cell viability for 48 h. The 5637 cells were treated with compounds 4, 5, 7, 8, 10, and 13 at a concentration of 0.1 µM, 1 µM, and 10 µM for 24 h and 48 h. Cell viability was measured by MTT assay.